Pancreatic intraepithelial neoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K<sup>+</sup> channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC. by immunohistochemical analysis of pancreatic tissue sections from Pdx1-Cre; LSL-Kras<sup>G12D/+</sup> mice (KC), Pdx1-Cre; LSL-Kras<sup>G12D/+</sup>; LSL-Trp53<sup>R172H/+</sup> mice (KPC) and human PDAC tissue microarrays, we found that Ca<sup>2+</sup>-activated K<sup>+</sup> channel KCNN4 was significantly elevated in pancreatic intraepithelial neoplasia (PanIN) and PDAC epithelia compared with untransformed pancreas tissues.
|
29050937 |
2017 |
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The HOHO European protocol is a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns.
|
31362134 |
2019 |
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke.
|
26718567 |
2016 |
Hyperplasia
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
Thus, KCNK1 suppresses phenobarbital-induced hyperplasia.
|
23291559 |
2013 |
Heart valve disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
For example, phospholamban, the beta-subunit MinK (KCNE1) and MIRP2 (KCNE3), and the 2-pore potassium channel TWIK-1 were upregulated in AF-VHD compared with SR-VHD, whereas the T-type calcium-channel Cav3.1 and the transient-outward potassium channel Kv4.3 were downregulated.
|
16027256 |
2005 |
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An essential suppressor of anchorage-independent growth is KCNK1, which is directly transactivated by TAp73 and commonly downregulated in glioma, melanoma and ovarian cancer.
|
18239687 |
2008 |
Deafness
|
0.200 |
Biomarker
|
phenotype |
RGD |
TWIK-1 was significantly decreased at 3 weeks and 3 months following deafness and TREK-2 was only significantly decreased at 3 days.
|
17884299 |
2007 |
Chronic Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Six genes showed evidence of statistically significant association: 4 with severe CP (NIN, p = 1.6 × 10(-7); ABHD12B, p = 3.6 × 10(-7); WHAMM, p = 1.7 × 10(-6); AP3B2, p = 2.2 × 10(-6)) and 2 with high periodontal pathogen colonization (red complex-KCNK1, p = 3.4 × 10(-7); Porphyromonas gingivalis-DAB2IP, p = 1.0 × 10(-6)).
|
25056994 |
2014 |
Chronic Obstructive Airway Disease
|
0.110 |
GeneticVariation
|
disease |
BEFREE |
We identified suggestive association with BDR among COPD subjects for variants near two potassium channel genes (KCNK1 and KCNJ2).
|
26503814 |
2016 |
Chronic Obstructive Airway Disease
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease.
|
26503814 |
2016 |
Brugada Syndrome (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nav1.5 and K(+)-channels Kv4.3 and Kir3.4 were more weakly expressed, whereas the Na(+)-channel Nav2.1 and the K(+)-channel TWIK1 were more strongly expressed, in Brugada syndrome.
|
19029124 |
2009 |
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The HOHO European protocol is a prospective multicenter cohort study of young women with newly diagnosed breast cancer, about fertility, psychosocial and quality of life concerns.
|
31362134 |
2019 |
Atrial Fibrillation
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To determine whether genetic variants in KCNK1 might cause atrial fibrillation (AF), we sequenced protein-coding regions in two independent cohorts of patients (373 subjects) and identified three non-synonymous variants, p.R171H, p.I198M and p.G236S, that were all located in highly conserved amino acid residues.
|
27103460 |
2016 |
Atrial Fibrillation
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
For example, phospholamban, the beta-subunit MinK (KCNE1) and MIRP2 (KCNE3), and the 2-pore potassium channel TWIK-1 were upregulated in AF-VHD compared with SR-VHD, whereas the T-type calcium-channel Cav3.1 and the transient-outward potassium channel Kv4.3 were downregulated.
|
16027256 |
2005 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, by screening a GEO dataset containing 36 microdissected PDAC and matching normal pancreatic tissue samples, four differentially expressed K<sup>+</sup> channels (KCNJ5, KCNJ16, KCNN4 and KCNK1) were identified in PDAC. by immunohistochemical analysis of pancreatic tissue sections from Pdx1-Cre; LSL-Kras<sup>G12D/+</sup> mice (KC), Pdx1-Cre; LSL-Kras<sup>G12D/+</sup>; LSL-Trp53<sup>R172H/+</sup> mice (KPC) and human PDAC tissue microarrays, we found that Ca<sup>2+</sup>-activated K<sup>+</sup> channel KCNN4 was significantly elevated in pancreatic intraepithelial neoplasia (PanIN) and PDAC epithelia compared with untransformed pancreas tissues.
|
29050937 |
2017 |
AIDS Dementia Complex
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nucleotide sequence analysis of the two cDNAs identified known genes not previously associated with the pathogenesis of AIDS dementia, including the neurotrophin receptor tyrosine kinase receptor B (TrkB) and the potassium channel human open rectifyer K+ channel (ORK) homologous open reading frame (HOHO1).
|
11471556 |
2001 |